Meet Our Plenary Speakers: PL04 Noboru Hiroi, USA
‘Modeling and Predicting Developmental Trajectories of Neuropsychiatric Dimensions’
Various cognitive capacities, such as executive functions and social cognition, continually develop from childhood to adulthood and the developmental trajectories of these dimensions derail in individuals with neuropsychiatric disorders. However, it is not well understood how such atypical cognitive dimensions contribute to the onset of neuropsychiatric disorders. Moreover, the mechanistic basis through which genetic variants determine the trajectories of cognitive dimensions is still poorly understood. Knowledge of these two aspects is essential to develop mechanism-based therapeutic options. I will present the latest advances in our understanding of:
1) how variants of individual genes encoded in 22q11.2 copy number variants alter the developmental trajectories of cognitive dimensions and
2) potential neuronal substrates underlying such processes in mouse and cell models
Noboru Hiroi, PhD, is interested in the genetic, cellular and molecular mechanisms underlying developmental neuropsychiatric disorders. He is currently identifying specific genes responsible for dimensional aspects of schizophrenia and autism using mouse and cell models of copy number variants at human chromosome 22q11.2. His recent findings have identified Tbx1 and COMT as two 22q11.2 genes that contribute to the developmental trajectories of social communication and working memory, respectively.
Dr. Hiroi completed his undergraduate education at Waseda University, Japan, in 1985 and earned his PhD at McGill University (Dean’s honor list), Canada, in 1991. His background in behavioral neuroscience has grown and diversified over the years with experience in the laboratories of Dr. Ann M. Graybiel at MIT and of Dr. Eric J. Nestler at Yale University School of Medicine.
Dr. Hiroi started his own laboratory in 1998 as an Assistant Professor at Albert Einstein College of Medicine, New York, became Associate Professor in 2005 and Professor in 2011. He was awarded an NARSAD Young Investigator Award in 1998, a NARSAD Independent Investigator Award in 2006, and the Lilly Basic Neuroscience Award in 2016. He serves on the editorial boards of Biological Psychiatry and Neuropsychopharmacology.
Professor Hiroi’s Plenary Lecture will take place on Monday 18th June 2018 in the Main Auditorium (Hall E) from 16.45 – 17.30. Visit www.cinp.org/vienna to view the full Preliminary Programme