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Literature Updates

  • December 19, 2018 15:50 | CINP Office (Administrator)

    The symptoms of major depressive disorder (MDD) are rapidly alleviated by administration of a single dose of the glutamatergic modulator ketamine. However, few studies have investigated the potential sustained neural effects of this agent beyond immediate infusion. This study used functional magnetic resonance imaging to examine the effect of a single ketamine infusion on the resting state default mode network (DMN) at 2 and 10 days after a single ketamine infusion in unmedicated subjects with MDD as well as healthy control subjects (HCs).

    Evans JW, Szczepanik J, Brutsché N, Park LT, Nugent AC, Zarate CA Jr.

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  • December 19, 2018 15:49 | CINP Office (Administrator)

    The negative allosteric modulators (NAMs: L-655,708 and MRK-016) of α5 subunit-containing GABAA receptors are reported to show rapid-acting antidepressant effects in rodents. However, there are no reports comparing these NAMs and (R)‑ketamine, (R)-enantiomer of the rapid-acting antidepressant ketamine, in a chronic social defeat stress (CSDS) model.

    Xiong Z, Zhang K, Ishima T, Ren Q, Chang L, Chen J, Hashimoto K.

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  • December 19, 2018 11:41 | CINP Office (Administrator)

    Individuals with stress-related psychiatric disorders exhibit deficits in cognitive flexibility. We have shown that chronic intermittent cold stress induces deficits in reversal learning, a form of cognitive flexibility mediated in the orbitofrontal cortex, that was reversed by ketamine in male rats. Such effects have not been tested in females. In this study, we examined effects of chronic intermittent cold stress and ketamine on reversal learning in females.

    Denisse Paredes; Jeri D Silva; David A Morilak.

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  • December 19, 2018 11:39 | CINP Office (Administrator)

    A markedly reduced interest or pleasure in activities previously considered pleasurable is a main symptom in mood disorder and psychosis and is often present in other psychiatric disorders and neurodegenerative diseases. This condition can be labeled as “anhedonia,” although in its most rigorous connotation the term refers to the lost capacity to feel pleasure that is one aspect of the complex phenomenon of processing and responding to reward. The responses to rewarding stimuli are relatively easy to study in rodents, and the experimental conditions that consistently and persistently impair these responses are used to model anhedonia. To this end, long-term exposure to environmental aversive conditions is primarily used, and the resulting deficits in reward responses are often accompanied by other deficits that are mainly reminiscent of clinical depressive symptoms.

    Simona Scheggi; Maria Graziella De Montis; Carla Gambarana.

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  • December 19, 2018 11:34 | CINP Office (Administrator)

    Identification of biomarkers predicting therapeutic outcome of antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right treatment for a given individual with depression. In the current study, we explored the potential of pretreatment pregenual anterior cingulate cortex activity as a putative biomarker of treatment response.

    Beata R Godlewska; Michael Browning; Ray Norbury; Artemis Igoumenou; Philip J Cowen; Catherine J Harmer.

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