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  • Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis

Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis

February 25, 2019 16:21 | CINP Office (Administrator)

Background
Electroconvulsive therapy (ECT) is the treatment of choice for severe mental illness including treatment-resistant depression (TRD). Increases in volume of the hippocampus and amygdala following ECT have consistently been reported.

Aims
To investigate neuroplastic changes after ECT in specific hippocampal subfields and amygdala nuclei using high-resolution structural magnetic resonance imaging (MRI) (trial registration: clinicaltrials.gov – NCT02379767).

Gregor Gryglewski, Pia Baldinger-Melich, René Seiger, Godber Mathis Godbersen, Paul Michenthaler, Manfred Klöbl, Benjamin Spurny, Alexander Kautzky, Thomas Vanicek, Siegfried Kasper, Richard Frey and Rupert Lanzenberger. 

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